Plasminogen Activator Inhibitor-1 Secretion by Endothelial Cells Increases Fibrinolytic Resistance of an In Vitro Fibrin Clot: Evidence for a Key Role of Endothelial Cells in Thrombolytic Resistance
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چکیده
Time-dependent thrombolytic resistance is a critical problem in thrombolytic therapy for acute myocardial infarction. Platelets have been regarded as the main source of plasminogen activator inhibitor-1 (PAI-1) found in occlusive plateletrich clots. However, endothelial cells are also known to influence the fibrinolytic capacity of blood vessels, but their ability to actively mediate time-dependent thrombolytic resistance has not been fully established. We will show that, in vitro, tumor necrosis factor-cr-stimulated endothelial cells secrete large amounts of PAL1 over a period of hours, which
منابع مشابه
Plasminogen activator inhibitor-1 secretion of endothelial cells increases fibrinolytic resistance of an in vitro fibrin clot: evidence for a key role of endothelial cells in thrombolytic resistance.
Time-dependent thrombolytic resistance is a critical problem in thrombolytic therapy for acute myocardial infarction. Platelets have been regarded as the main source of plasminogen activator inhibitor-1 (PAI-1) found in occlusive platelet-rich clots. However, endothelial cells are also known to influence the fibrinolytic capacity of blood vessels, but their ability to actively mediate time-depe...
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change, although active PAI-1 changed to latent PAI-1 as a result of freezing and thawing. Although it is thought that measuring active PAI-1 concentrations is the best way to evaluate the inhibitory ability of tPA, active PAI-1 quickly loses its activity with time as a result of conformational changes. We therefore believe that the activity assay does not reflect the real PAI-1 activity of pla...
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Background: Plasminogen has a central role in fibrinolyrtic system can activate through various activators (PAs) to its active form plasmin and perfoem its vital function that is fibrin clot lysis. Furthermore the fibrinolyrtic system plays a major role in angiogenesis. The fibrinolyrtic system activation control cell migration and invasion. In addition to this, plasmin regulates tumor growth. ...
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